Triethylamine → N-Methyl-N-[(1-methyl-2-indolyl)methyl]acrylamide
반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[CH2:11][NH:12][CH3:13].CCN(CC)CC.[C:21](Cl)(=[O:24])[CH:22]=[CH2:23]>C(Cl)Cl>[CH3:13][N:12]([CH2:11][C:3]1[N:2]([CH3:1])[C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:21](=[O:24])[CH:22]=[CH2:23]참가 물질
5
실험 절차
To a stirred solution of 1-methyl-2-(methylaminomethyl)-1H-indole (1.5 g, 8.6 mmole) and Et3N (1.35 mL, 9.6 mmole) in CH2Cl2 (75 mL) at 0° C. was added dropwise acryloyl chloride (0.77 mL, 9.5 mmole) over 5 minutes. After 2 h the reaction was washed with cold H2O, brine, dried (MgSO4) and concentrated under vacuum. The residue was used without further purification.
후처리
- washAfter 2 h the reaction was washed with cold H2O, brine
- dry with materialdried (MgSO4)
- concentrationconcentrated under vacuum
- customThe residue was used without further purification
출처 및 근거
- ORD 기록
- ord-30357a7fd7e343fdbec400f6fdc43a62
- 출처 데이터셋
- uspto-grants-2009_07
- 특허 번호
- US07557125B2
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