Hydrochloric Acid → 4-Fluoro-cinnamyl chloride

273.6 g (1.798 mol) of 1-(4-fluorophenyl)allyl alcohol were dissolved with stirring in 2,000 ml of methylene chloride. Subsequently, 101.0 g (2,770 mol) of hydrogen chloride were passed in over the course of 3 h, during which the temperature rose to 37° C. The mixture was then stirred for 1 h. After washing with 600 ml of ice-cold water and a mixture of 150 ml of saturated brine and 150 ml of water, the organic phase was dried over sodium sulfate and concentrated. 294.6 g (98%) of a brown oil were obtained.

1. customwere passed in over the course of 3 h, during which
2. customrose to 37° C
3. washAfter washing with 600 ml of ice-cold water
4. additiona mixture of 150 ml of saturated brine and 150 ml of water
5. dry with materialthe organic phase was dried over sodium sulfate
6. concentrationconcentrated

ORD 기록

ord-9c2abfae17fa4ef4a5431eb346963d08

출처 데이터셋

uspto-grants-1995_12

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05473080