Triphenylphosphine → ((3-Chlorothieno[3,2-b]pyridin-5-yl)methyl)triphenylphosphonium chloride

HRID 2259486노트

반응식

HRID 2259486 반응식
[Cl:1][C:2]1[C:6]2=[N:7][C:8]([CH2:11]Cl)=[CH:9][CH:10]=[C:5]2[S:4][CH:3]=1.[P:13]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CC#N>[Cl-:1].[Cl:1][C:2]1[C:6]2=[N:7][C:8]([CH2:11][P+:13]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:9][CH:10]=[C:5]2[S:4][CH:3]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 190028563-Chloro-5-(chloromethyl)thieno[3,2-b]-pyridine

생성물 1

HCID 88252540((3-Chlorothieno[3,2-b]pyridin-5-yl)methyl)triphenylphosphonium chloride수율 159%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 3-chloro-5-(chloromethyl)thieno[3,2-b]-pyridine (1.2 g, 5.5 mmol) in CH3CN (20 mL) was added P(Ph)3 (2.88 g, 11 mmol). The mixture was refluxed for 20 hr. and was then evaporated to dryness. Et2O (8 mL) was added. The mixture was stirred vigorously and the crystalline salt was filtered and washed with more Et2O to give. 2.1 g (81%) of the title compound.

후처리

  1. temperatureThe mixture was refluxed for 20 hr
  2. customand was then evaporated to dryness
  3. additionEt2O (8 mL) was added
  4. filtrationthe crystalline salt was filtered
  5. washwashed with more Et2O
  6. customto give

출처 및 근거

ORD 기록
ord-e9627dcfb2e64002af7c87094f894747
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05472964

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