1-Bromopropane → HCID 19001410, 화합물

HRID 2259558노트

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HRID 2259558 반응식
[NH:1]1[C:5]([C:6]2[C:11](=[O:12])[N:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4][N:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].[CH2:23](Br)[CH2:24][CH3:25]>CN(C)C=O>[CH2:23]([N:3]1[N:2]=[N:1][C:5]([C:6]2[C:11](=[O:12])[N:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4]1)[CH2:24][CH3:25]

참가 물질

5

반응물 3

HCID 78401-BromopropaneHCID 11430Potassium CarbonateHCID 178515422HCID 178515422, 화합물

생성물 1

HCID 19001410HCID 19001410, 화합물수율 31.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
90 °C

실험 절차

A mixture of 0.4 g (0.00187 moles) of 3-(1H-tetrazol-5-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine, 15 ml of dimethylformamide, 0.25 g (0.00187 moles) of anhydrous potassium carbonate and 0.34 ml (0.00374 moles) of propyl bromide was stirred at 90° C. for 1 hour. The hot dark brown solution was filtered, and the filtrate was evaporated. The dark brown oily residue, which is the mixture of the title compounds, started to crystallize. To the oily crystals 10 ml of ethanol were added, and the crystals were collected. 0.15 g (31.3%) of 3-(2-propyl-2H-tetrazol-5-yl)-4-oxo-4H-pyrido[1,2 -a]pyrimidine was obtained, in the form of pale-yellow crystals, m.p.: 115°-116° C.

후처리

  1. filtrationThe hot dark brown solution was filtered
  2. customthe filtrate was evaporated
  3. additionthe mixture of the title compounds
  4. customto crystallize
  5. additionTo the oily crystals 10 ml of ethanol were added
  6. customthe crystals were collected

출처 및 근거

ORD 기록
ord-60caeacbcae745d2b73080a0aeea5e6d
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05475000

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