Methyl o-toluate → Methyl 2-(bromomethyl)benzoate
반응식
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[Br:12]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:12][CH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]참가 물질
5
실험 절차
To a mixture of methyl 2-methylbenzoate (5.0 g, 0.033 mmol) and N-bromosuccinimide (5.9 g, 0.033 mmol) in CCl4 (50 mL) was added benzoyl peroxide (0.04 g, 0.00016 mmol). The mixture was heated to reflux for 1.5 h, cooled to room temperature, filtered through Celite, and concentrated to afford methyl 2-(bromomethyl)benzoate (7.2 g, ca. 94% mass recovery), which was contaminated with ca. 14% unreacted starting material and was used without purification.
후처리
- temperatureThe mixture was heated
- temperatureto reflux for 1.5 h
- filtrationfiltered through Celite
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-cf3f803730124b61b67889dd940bee60
- 출처 데이터셋
- uspto-grants-2009_07
- 특허 번호
- US07557135B2
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