Acetyl chloride → N-(2,3-dihydroxypropyl)-N-(hexadecyl)ethanamide

HRID 2260079

반응식

HRID 2260079 반응식
[C:1](Cl)(=[O:3])[CH3:2].[OH:5][CH:6]([CH2:25][OH:26])[CH2:7][NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>C(Cl)(Cl)Cl>[OH:5][CH:6]([CH2:25][OH:26])[CH2:7][N:8]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:1](=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 1110073-(Hexadecylamino)propane-1,2-diol

생성물 1

HCID 18999304N-(2,3-dihydroxypropyl)-N-(hexadecyl)ethanamide수율 26%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Acetyl chloride (1.15g. 14.8 mmoles) was added dropwise to a reactor containing N-(2,3-dihydroxypropyl)-hexadecylamine (1.5 g, 4.3 mmoles) in 3 mL of chloroform. The reaction was stirred for 16 hours at room temperature. When the reaction was completed, the, mixture was concentrated, ethanol and water was added, and the pH of the reaction was adjusted to 14. This mixture was extracted with chloroform, and organic layer was collected and concentrated. The sample was purified on a silica column chromatography to give 0.4 g of product.

후처리

  1. concentrationthe, mixture was concentrated
  2. additionethanol and water was added
  3. extractionThis mixture was extracted with chloroform, and organic layer
  4. customwas collected
  5. concentrationconcentrated
  6. customThe sample was purified on a silica column chromatography

출처 및 근거

ORD 기록
ord-8281afeacc564c11883c03f614970d5d
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05476661

연결된 노트

불러오는 중…