3,4-Dimethoxy-5-nitrobenzophenone → 3,4-Dihydroxy-5-nitrobenzophenone

HRID 2260209노트

반응식

HRID 2260209 반응식
C[O:2][C:3]1[CH:4]=[C:5]([CH:14]=[C:15]([N+:19]([O-:21])=[O:20])[C:16]=1[O:17]C)[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7]>C(O)(=O)C.Br>[OH:2][C:3]1[CH:4]=[C:5]([CH:14]=[C:15]([N+:19]([O-:21])=[O:20])[C:16]=1[OH:17])[C:6]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7]

참가 물질

4

반응물 1

HCID 214590553,4-Dimethoxy-5-nitrobenzophenone

생성물 1

HCID 57479693,4-Dihydroxy-5-nitrobenzophenone

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매

실험 절차

0.5 g of 3,4-dimethoxy-5-nitrobenzophenone is stirred at 110° for 30 hours in a mixture of 4 ml of acetic acid and 4 ml of 48 percent aqueous hydrobromic acid. The reaction mixture is subsequently evaporated to dryness. The residue is taken up in methylene chloride. It is washed with water, dried over sodium sulfate and evaporated. After recrystallization from methylene chloride/hexane there is obtained 3,4-dihydroxy-5-nitrobenzophenone of m.p. 132°.

후처리

  1. customThe reaction mixture is subsequently evaporated to dryness
  2. washIt is washed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated
  5. customAfter recrystallization from methylene chloride/hexane there

출처 및 근거

ORD 기록
ord-7c281d826b424d72898748e7fa832188
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05476875

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