Acetyl chloride → N-(2-phenylpropan-2-yl)acetamide

HRID 2260565노트

반응식

HRID 2260565 반응식
[C:1](Cl)(=[O:3])[CH3:2].[C:5]([NH2:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[CH3:6].[OH-].[Na+].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[CH3:6][C:5]([NH:14][C:1](=[O:3])[CH3:2])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7]

참가 물질

6

반응물 4

HCID 6367Acetyl chlorideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 68509Cumylamine

생성물 1

HCID 10749810N-(2-phenylpropan-2-yl)acetamide수율 86.7%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Acetyl chloride (62 g) was dropwise added to a solution (1 l) of cumylamine (90 g) and a 48% aqueous solution of sodium hydroxide (70 ml) in toluene under ice-cooling and the mixture was stirred at room temperature for 5 hours. After completion of the reaction, the mixture was neutralized with a saturated aqueous solution of potassium carbonate and extracted with ethyl acetate. The extract was washed with water and dried. The solvent was distilled away under reduced pressure to give 102.3 g of N-(1-methyl-1-phenylethyl)acetamide.

후처리

  1. customAfter completion of the reaction
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. customdried
  5. distillationThe solvent was distilled away under reduced pressure

출처 및 근거

ORD 기록
ord-d3ceca01eb3a4569a2100843ff68ce52
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05478838

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