Ethyl benzoate → N-(2-hydroxyethyl)-N-methylbenzamide

HRID 2260708

반응식

HRID 2260708 반응식
[C:1]([O:9]CC)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:12][NH:13][CH2:14][CH2:15][OH:16]>O>[C:1]([N:13]([CH2:14][CH2:15][OH:16])[CH3:12])(=[O:9])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 7165Ethyl benzoateHCID 80162-(Methylamino)ethanol

생성물 1

HCID 4047264N-(2-hydroxyethyl)-N-methylbenzamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Ethyl benzoate (16.0 g, 15.3 ml) was dissolved in 2-(N-methylamino)ethanol (200 ml) and the mixture heated at reflux for 17.5 hours, cooled and diluted with water (1 l). The mixture was extracted with dichloromethane (4×200 ml), and the combined dichloromethane solutions washed with brine (300 ml), dried (MgSO4) and evaporated. The title compound, an oil, was used without further purification.

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 17.5 hours
  3. temperaturecooled
  4. extractionThe mixture was extracted with dichloromethane (4×200 ml)
  5. washthe combined dichloromethane solutions washed with brine (300 ml)
  6. dry with materialdried (MgSO4)
  7. customevaporated
  8. customThe title compound, an oil, was used without further purification

출처 및 근거

ORD 기록
ord-b1e3069bf01a4dadac9d2d81c0cd3018
출처 데이터셋
uspto-grants-1995_12
특허 번호
US05478851

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