Methylhydrazine → HCID 67548813, 화합물

HRID 2261010노트

반응식

HRID 2261010 반응식
F[C:2]1[C:7]([CH:8]=O)=[C:6]([I:10])[CH:5]=[CH:4][N:3]=1.[CH3:11][NH:12][NH2:13]>>[I:10][C:6]1[CH:5]=[CH:4][N:3]=[C:2]2[N:12]([CH3:11])[N:13]=[CH:8][C:7]=12

참가 물질

3

반응물 2

HCID 6061MethylhydrazineHCID 99923282-Fluoro-4-iodopyridine-3-carbaldehyde

생성물 1

HCID 67548813HCID 67548813, 화합물

실험 절차

227 mg of 2-fluoro-4-iodo-pyridine-3-carbaldehyde (0.9 mmol, 1 eq.; prepared as described in J. Org. Chem. 1993, 58, 7832) were dissolved in 3.6 mL 1-PrOH, treated with 72 μL methyl hydrazine (1.36 mmol, 1.5 eq.) and heated to 100° C. for 30 min (Biotage Initiator 60®). The reaction mixture was concentrated in vacuo, the residue was partioned between water and ethyl acetate, the aq. layer was extracted with ethyl acetate, the combined organic layers were dried and concentrated in vacuo to provide the crude target compound.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. extractionthe aq. layer was extracted with ethyl acetate
  3. customthe combined organic layers were dried
  4. concentrationconcentrated in vacuo
  5. customto provide the crude target compound

출처 및 근거

ORD 기록
ord-48cca360379648a7a0de081b6ed67cb3
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07846928B2

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