Acetic Acid → Ethyl 3-hydroxy-3,6-dihydropyridine-1(2H)-carboxylate
반응식
C([O:4][CH:5]1[CH2:10][N:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:8][CH:7]=[CH:6]1)(=O)C.[OH-].[Na+].C(O)(=O)C>CCO>[OH:4][CH:5]1[CH2:10][N:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:8][CH:7]=[CH:6]1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of Compound 239B (10.5 g, 49.2 mmol) in 30 mL of EtOH was added a solution of 0.2N NaOH in EtOH (65 mL) and the mixture was stirred at 0° C. for 30 min. After warming to room temperature, the reaction mixture was neutralized with glacial acetic acid. Concentration in vacuo afforded 8.5 g of 239C as an oil. 1H-NMR (400 MHz, CDCl3): 5.90 (m, 1H), 5.82 (bs, 1H), 4.20 (bs, 1H), 4.18 (q, J=7.08, 2H), 4.04 (m, 1H), 3.85 (m, 1H), 3.55 (m, 2H), 1.28 (t, J=7.08, 3H).
후처리
- temperatureAfter warming to room temperature
- concentrationConcentration in vacuo
출처 및 근거
- ORD 기록
- ord-75b04e74acff4d0b90d63fd555ad2224
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07846931B2
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