Water → HCID 57736326, 화합물
반응식
[CH3:1][C:2]([C:8]1[O:12][N:11]=[C:10]([C:13](OCC)=[O:14])[CH:9]=1)([O:4][CH2:5][C:6]#[CH:7])[CH3:3].[BH4-].[Na+].O>C(O)C>[CH3:3][C:2]([C:8]1[O:12][N:11]=[C:10]([CH2:13][OH:14])[CH:9]=1)([O:4][CH2:5][C:6]#[CH:7])[CH3:1]참가 물질
5
실험 절차
0.25 g of ethyl 5-[1-methyl-1-(2-propynyloxy)ethyl]isoxazole-3-carboxylate was dissolved in 2 ml of ethanol, and 0.1 g of sodium borohydride was then added. The mixture was stirred at room temperature for 5 hours. After 20 ml of water was added, the reaction mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.20 g of {5-[1-methyl-1-(2-propynyloxy)ethyl]isoxazol-3-yl}methanol.
후처리
- extractionthe reaction mixture was extracted with ethyl acetate
- dry with materialThe organic layer was dried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-853e9efc2803403d964bec3a6ee8f796
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07846956B2
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