Hydrochloric Acid → 2-(4-Amino-3-nitrobenzoyl)benzoic acid

HRID 2261924노트

반응식

HRID 2261924 반응식
Cl[C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10]([OH:12])=[O:11])=[O:7])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].Cl.[OH-].[NH4+:24]>>[NH2:24][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10]([OH:12])=[O:11])=[O:7])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 665622-(4-Chloro-3-nitrobenzoyl)benzoic acid

생성물 1

HCID 27975222-(4-Amino-3-nitrobenzoyl)benzoic acid수율 98%

실험 절차

A solution of 2-(4-chloro-3-nitrobenzoyl)benzoic acid (5.0 g, 16.36 mmol) was heated to reflux in 28-30% aq. ammonium hydroxide (100 mL) for 18 h. The solution was cooled to room temperature followed by addition of 6N aq. hydrochloric acid until pH to 7. The precipitated yellow solid was collected by filtration and washed with water then dried in vacuo to provide 2-[(4-amino-3-nitrophenyl)carbonyl]benzoic acid (4.60 g, 98%). MS (EI) for C14H10N2O5: 288 (MH+).

후처리

  1. filtrationThe precipitated yellow solid was collected by filtration
  2. washwashed with water
  3. customthen dried in vacuo

출처 및 근거

ORD 기록
ord-106c24324f614c2690e00df2af337fbd
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07846959B2

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