4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide → 4-Amino-N-[2-(diethylamino)ethyl]-2-methoxybenzamide

HRID 2262349

반응식

HRID 2262349 반응식
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[O:9])=[C:6]([O:20][CH3:21])[CH:5]=1)([O-])=O>O1CCCC1.C(O)C.[Pd]>[NH2:1][C:4]1[CH:19]=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH2:12][N:13]([CH2:14][CH3:15])[CH2:16][CH3:17])=[O:9])=[C:6]([O:20][CH3:21])[CH:5]=1

참가 물질

4

반응물 1

HCID 4088914-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide

생성물 1

HCID 773744-Amino-N-[2-(diethylamino)ethyl]-2-methoxybenzamide수율 106.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

5.7 g (19.3 mmol) of 4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide is dissolved in 120 ml of tetrahydrofuran:ethanol 1:1>mixed with 2 g of palladium on carbon (10%×50% water) and hydrogenated for 1 hour at room temperature and normal pressure. After being drawn off on diatomaceous earth and after concentration by evaporation, 5.45 g of 4-amino-N-(2-diethylamino-ethyl)-2-methoxy-benzamide is obtained.

후처리

  1. concentrationafter concentration
  2. customby evaporation

출처 및 근거

ORD 기록
ord-fec49c96a0654ddaa3d16ec6f4872d02
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07850948B2

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