Ethyl bromoacetate → (2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester

HRID 226263

반응식

HRID 226263 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[OH:12])=[O:3].C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>CCC(C)=O>[CH2:24]([O:23][C:21](=[O:22])[CH2:20][O:12][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH3:11])=[CH:9][C:4]=1[C:2](=[O:3])[CH3:1])[CH3:25]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 697141-(2-Hydroxy-5-methoxyphenyl)ethan-1-one

생성물 1

HCID 15643798(2-Acetyl-4-methoxy-phenoxy)-acetic acid ethyl ester

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 16.6 g (100.0 mmol) of 2-hydroxi-5-methoxyacetophenone, 20 g (208 mmol) of potassium carbonate, 16.7 g (100.0 mmol) of ethyl bromoacetate and 200 ml of MEK is stirred at reflux temperature for 10 hr. The solids are filtered and the filtrate concentrated. The residue is suspended in water and the solid is filtered and dried. Yield: 10.2 g (40%).

후처리

  1. temperatureat reflux temperature for 10 hr
  2. filtrationThe solids are filtered
  3. concentrationthe filtrate concentrated
  4. filtrationthe solid is filtered
  5. customdried

출처 및 근거

ORD 기록
ord-60bd36e5ee7d4e22abc36d0cbb75c24c
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557212B2

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