Hydrochloric Acid → 1-(4-Phenyl-1,3-oxazol-2-yl)piperazine

HRID 2262901노트

반응식

HRID 2262901 반응식
[C:1]1([C:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[O:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>O1CCCC1.CO.C(OCC)(=O)C>[C:1]1([C:7]2[N:8]=[C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[O:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 68777431Tert-butyl 4-(4-phenyl-1,3-oxazol-2-yl)piperazine-1-carboxylate

생성물 1

HCID 687757351-(4-Phenyl-1,3-oxazol-2-yl)piperazine수율 90.2%

시약·촉매·용매 3

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of tert-butyl 4-(4-phenyl-1,3-oxazol-2-yl)piperazine-1-carboxylate (590 mg, 1.79 mmol) in tetrahydrofuran (4 ml) and methanol (4 ml) was added a solution of 4 N hydrogen chloride in ethyl acetate (4 ml), and the mixture was stirred at room temperature for 1 hour. The solvent was distilled off under reduced pressure. The residue was poured to an aqueous 1 N sodium hydroxide solution (10 ml) and extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to give 370 mg (90.0%) of the desired product as an oil.

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. additionThe residue was poured to an aqueous 1 N sodium hydroxide solution (10 ml)
  3. extractionextracted with chloroform
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-27bd0f892f104f3793209c30ee1a4cde
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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