Hydrochloric Acid → HCID 68780272, 화합물

HRID 2263026노트

반응식

HRID 2263026 반응식
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:10]=[C:9]([N:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[S:8][N:7]=2)=[CH:2]1.Cl.CCCCCC>C(OCC)(=O)C>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:10]=[C:9]([N:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[S:8][N:7]=2)=[CH:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 68778008tert-Butyl 4-[3-(3-thienyl)-1,2,4-thiadiazol-5-yl]piperazine-1-carboxylate

생성물 1

HCID 68780272HCID 68780272, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of tert-butyl 4-[3-(3-thienyl)-1,2,4-thiadiazol-5-yl]piperazine-1-carboxylate (3.70 g, 10.5 mmol) in ethyl acetate (60 ml) was added a solution of 4 N hydrochloric acid in ethyl acetate (30 ml), and the mixture was stirred at room temperature for 22 hours. Hexane (200 ml) was poured to the reaction mixture, and a solid was separated by filtration. The obtained solid was dissolved in an aqueous saturated sodium hydrogen carbonate solution, followed by stirring at room temperature for 2 hours. Water was poured to the reaction mixture, and 1.86 g (70.4%) of the desired product as a solid was separated by filtration.

후처리

  1. customa solid was separated by filtration
  2. dissolutionThe obtained solid was dissolved in an aqueous saturated sodium hydrogen carbonate solution
  3. stirringby stirring at room temperature for 2 hours
  4. additionWater was poured to the reaction mixture, and 1.86 g (70.4%) of the desired product as a solid
  5. customwas separated by filtration

출처 및 근거

ORD 기록
ord-765a388331504de3ad5f5a179000c29a
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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