2-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine hydrochloride → 2-Methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine
반응식
Cl.[CH3:2][CH:3]1[CH2:8][NH:7][CH2:6][CH2:5][N:4]1[C:9]1[S:13][N:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:10]=1>[OH-].[Na+]>[CH3:2][CH:3]1[CH2:8][NH:7][CH2:6][CH2:5][N:4]1[C:9]1[S:13][N:12]=[C:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:10]=1참가 물질
3
실험 절차
To 2-methyl-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine hydrochloride (500 mg, 1.68 mmol) was added an aqueous 1N sodium hydroxide solution (10 ml) and the mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (438 mg, 100%) as oil.
후처리
- extractionthe mixture was extracted with chloroform
- dry with materialThe extract was dried over anhydrous magnesium sulfate
- distillationthe solvent was distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-6971592717bf4aa88bc8b51c68a39626
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07851473B2
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