Sodium Hydroxide → 1-(4-Phenyl-2-thienyl)piperazine

HRID 2263054노트

반응식

HRID 2263054 반응식
[C:1]1([C:7]2[CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OCC)=O)[CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([C:7]2[CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 68776928Ethyl 4-(4-phenyl-2-thienyl)piperazine-1-carboxylate

생성물 1

HCID 687773121-(4-Phenyl-2-thienyl)piperazine수율 88.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of ethyl 4-(4-phenyl-2-thienyl)piperazine-1-carboxylate (350 mg, 1.11 mmol), an aqueous 8N sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 100° C. for 3 hours, and the solvent was distilled off under reduced pressure. The residue was poured into water and the mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to obtain the desired product (240 mg, 88.9%) as an oil.

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionThe residue was poured into water
  3. extractionthe mixture was extracted with chloroform
  4. dry with materialThe extract was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-bfd9f8f126d74528a7d5c78541ca744c
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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