Water → Thiocyanic acid, 2-(2-fluorophenyl)-2-oxoethyl ester

HRID 2263175노트

반응식

HRID 2263175 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11])=[O:4].[S-:12][C:13]#[N:14].[K+].O>C(O)C>[F:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 516872Potassium thiocyanateHCID 27374492-Bromo-2'-fluoroacetophenone

생성물 1

HCID 18526224Thiocyanic acid, 2-(2-fluorophenyl)-2-oxoethyl ester수율 95.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-bromo-1-(2-fluorophenyl)ethanone (5.00 g, 23.0 mmol) and potassium thiocyanate (2.24 g, 23.0 mmol) in ethanol (50 ml) was stirred at 80° C. for 2 hours. After cooling to room temperature, water (60 ml) was poured into the reaction solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product (4.29 g, 95.5%) as a solid.

후처리

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-96725ae2fc564cedb3af24ca0bc94c03
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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