Sodium Hydroxide → 1-[4-(4-Fluorophenyl)-2-thiazolyl]piperazine

HRID 2263188

반응식

HRID 2263188 반응식
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>O>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([N:14]3[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[S:12][CH:13]=2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 687781261-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine hydrochloride

생성물 1

HCID 80272011-[4-(4-Fluorophenyl)-2-thiazolyl]piperazine수율 89%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]piperazine hydrochloride (1.00 g, 2.97 mmol) was dissolved in water. The solution was neutralized with 1N aqueous sodium hydroxide solution, and the mixture was extracted with chloroform. The extract was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the desired product (696 mg, 67.2%) as an oil.

후처리

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-1f68d41a50c640ff88e42ef17cbce328
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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