Methanol → Pyrrolidinone, (4-aminophenyl)-

HRID 2263231

반응식

HRID 2263231 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[CH:6][CH:5]=1)([O-])=O.CO>[Pd].O1CCCC1>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 887MethanolHCID 2993281-(4-Nitrophenyl)pyrrolidin-2-one

생성물 1

HCID 676146Pyrrolidinone, (4-aminophenyl)-수율 92.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 1-(4-nitrophenyl)pyrrolidin-2-one (1.00 g, 4.85 mmol), 10% palladium on carbon (100 mg), methanol (20 ml) and tetrahydrofuran (20 ml) was stirred under hydrogen atmosphere for 12 hours, insoluble substances were removed by filtration, and the filtrate was concentrated to give 790 mg (92.5%) of the desired product as an oil.

후처리

  1. custominsoluble substances were removed by filtration
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-e710ceef379b475083c097f649ae98ea
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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