Hydrochloric Acid → 1-[4-(3-Methylphenyl)-1,3-thiazol-2-yl]piperazine

HRID 2263305노트

반응식

HRID 2263305 반응식
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)[S:12][CH:13]=2)[CH:6]=[CH:7][CH:8]=1>C(OCC)(=O)C>[CH3:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[S:12][CH:13]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68778457HCID 68778457, 화합물

생성물 1

HCID 617815611-[4-(3-Methylphenyl)-1,3-thiazol-2-yl]piperazine수율 63.1%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

A 4 N solution (50 ml) of hydrogen chloride in ethyl acetate was added to a solution of tert-butyl 4-[4-(3-methylphenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate (2.00 g, 5.56 mmol) in ethyl acetate (50 ml), the mixture was stirred at room temperature for 12 hours, and the solvent was distilled off under reduced pressure. The residue was dissolved in water, neutralized with a 1 N sodium hydroxide aqueous solution, and extracted with chloroform. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give 910 mg (62.9%) of the desired product as an oil.

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with chloroform
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-9080338f40fb469192b55ba9bcb7a7c4
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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