Hydrochloric Acid → HCID 21100174, 화합물

HRID 2263328노트

반응식

HRID 2263328 반응식
Cl.[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[C:10]1[N:11]=[C:12]([N:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[S:13][CH:14]=1>C(OCC)(=O)C>[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[C:10]1[N:11]=[C:12]([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[S:13][CH:14]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68776393Tert-butyl 4-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate

생성물 1

HCID 21100174HCID 21100174, 화합물수율 83.3%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

A 4 N solution (70 ml) of hydrogen chloride in ethyl acetate was added to a solution of tert-butyl 4-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]piperazine-1-carboxylate (2.31 g, 5.58 mmol) in ethyl acetate (70 ml), the mixture was stirred at room temperature for 12 hours, and the solvent was distilled off under reduced pressure. The residue was dissolved in water, neutralized with a 1 N sodium hydroxide aqueous solution, and extracted with chloroform. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give 1.46 g (83.3%) of the desired product as a solid.

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with chloroform
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-a7a1c7e933b043278f22ef578718eb63
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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