Water → tert-Butyl 2-(3-cyanophenyl)-3-propylcarbazate

HRID 22637노트

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HRID 22637 반응식
[C:1]([C:3]1[CH:4]=[C:5]([N:9]([N:17]([CH2:24][CH2:25][CH3:26])C(=O)C(F)(F)F)[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].O.[OH-].[Li+]>CO>[C:1]([C:3]1[CH:4]=[C:5]([N:9]([NH:17][CH2:24][CH2:25][CH3:26])[C:10]([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 22591513Tert-butyl 2-(3-cyanophenyl)-3-propyl-3-(2,2,2-trifluoracetyl)carbazate

생성물 1

HCID 22591495tert-Butyl 2-(3-cyanophenyl)-3-propylcarbazate수율 63.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5.64 g (15.187 mmol) of crude product 403 are dissolved in 100 ml of methanol and treated at RT with 10 ml of completely deionized water and 1.08 g (45.24 mmol) of lithium hydroxide. The reaction mixture is then stirred for 5 h. After customary work-up, 2.67 g (63.8%) of 404 are thus obtained as an oil; MS(FAB)=276.

출처 및 근거

ORD 기록
ord-f82342c37f134165b376c8e3ea59ff61
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849626B2

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