Water → Ethyl 2-formylbiphenyl-4-carboxylate

HRID 2264315노트

반응식

HRID 2264315 반응식
Br[CH2:2][C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][C:4]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C[N+]1([O-])CC[O:24]CC1.O>C(#N)C>[CH:2]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][C:4]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:24]

참가 물질

5

반응물 3

HCID 962WaterHCID 82029Methyl morpholine oxideHCID 23112214Ethyl 2-(bromomethyl)biphenyl-4-carboxylate

생성물 1

HCID 23112255Ethyl 2-formylbiphenyl-4-carboxylate수율 66.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

In 100 ml of acetonitrile was dissolved 9.3 g of ethyl 2-(bromomethyl)biphenyl-4-carboxylate, and 7.0 g of N-methylmorpholine-N-oxide was added thereto at room temperature, followed by 4 hours of stirring. Water was added to the reaction solution, which was then extracted with ethyl acetate. The resulting organic layer was dried over anhydrous magnesium sulfate. After the solvent was removed by evaporation, the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate) to obtain 4.94 g of ethyl 2-formylbiphenyl-4-carboxylate as a white solid.

후처리

  1. additionwas added
  2. extractionwas then extracted with ethyl acetate
  3. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  4. customAfter the solvent was removed by evaporation
  5. customthe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate)

출처 및 근거

ORD 기록
ord-39d4fcae014745ec80f8fc90aaa7d548
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855198B2

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