Cyclopentylamine → 5-bromo-N-cyclopentyl-2-nitroaniline

HRID 2264362노트

반응식

HRID 2264362 반응식
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[C:8]1[CH:13]=[C:12]([Br:14])[CH:11]=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16]>C(O)CCC>[Br:14][C:12]1[CH:11]=[CH:10][C:9]([N+:15]([O-:17])=[O:16])=[C:8]([NH:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:13]=1

참가 물질

4

반응물 2

HCID 2906CyclopentylamineHCID 123156462,4-Dibromo-1-nitrobenzene

생성물 1

HCID 653413535-bromo-N-cyclopentyl-2-nitroaniline

시약·촉매·용매 1

HCID 2631-Butanol용매

반응 조건

온도
100 °C

실험 절차

Add cyclopentanamine (32 mL) to a solution of 2,4-dibromo-1-nitro-benzene (20 g) in 1-butanol (160 mL). Heat the mixture at 100° C. overnight. Remove the solvent under vacuum, add water and extract with EA. Wash the organic layer sequentially with an aqueous saturated solution of sodium bicarbonate and then water. Dry over magnesium sulfate and remove the solvent under vacuum to afford 22 g of the title compound. MS (ES+): m/z=286 (M+H)+.

후처리

  1. customRemove the solvent under vacuum
  2. additionadd water
  3. extractionextract with EA
  4. washWash the organic layer sequentially with an aqueous saturated solution of sodium bicarbonate
  5. dry with materialDry over magnesium sulfate
  6. customremove the solvent under vacuum

출처 및 근거

ORD 기록
ord-a3fe5ae5977840999ea2a400945b6900
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855211B2

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