Hydrochloric Acid → HCID 178478869, 화합물

HRID 2264425노트

반응식

HRID 2264425 반응식
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[N:18]=[C:17]([O:19]C)[CH:16]=[CH:15][N:14]=2)[CH2:8][CH2:7]1)=O)C.[ClH:21]>C(O)C>[ClH:21].[ClH:21].[NH:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13]2[N:18]=[C:17]([OH:19])[CH:16]=[CH:15][N:14]=2)[CH2:10][CH2:11]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 24237580Ethyl 4-[(4-methoxypyrimidin-2-yl)amino]piperidine-1-carboxylate

생성물 1

HCID 178478869HCID 178478869, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 4-(4-methoxy-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester (1.5 g, 5.35 mmol) in ethanol (50 mL) and conc. HCl (75 mL) was heated to reflux for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 194.9 [M+H]+.

후처리

  1. temperatureto reflux for 18 h
  2. customThe solvent was removed under reduced pressure
  3. customthe crude product used in the consecutive step without further purification

출처 및 근거

ORD 기록
ord-c15ad42c7ced438db05870c50bbf275b
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855194B2

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