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Hydrochloric Acid → [4-(2-Fluoro-phenyl)-quinazolin-2-yl]-piperidin-4-yl-amine dihydrochloride

HRID 2264453
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반응식

HRID 2264453 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:24]=[C:23]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[F:31])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>C(O)C.O1CCOCC1>[ClH:32].[ClH:32].[F:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[C:23]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:24]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 687810194-[4-(2-Fluoro-phenyl)-quinazolin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 68782336[4-(2-Fluoro-phenyl)-quinazolin-2-yl]-piperidin-4-yl-amine dihydrochloride

시약·촉매·용매 2

HCID 702Ethanol용매HCID 312751,4-Dioxane용매

실험 절차

A solution of 4-[4-(2-fluoro-phenyl)-quinazolin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (0.86 g, 2.04 mmol) in ethanol (5 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 322.9 [M+H]+.

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

출처 및 근거

ORD 기록
ord-0e28fe65357248df89693988652b81dd
출처 데이터셋
uspto-grants-2010_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07855194B2

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