Water → 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole

HRID 2264592

반응식

HRID 2264592 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][CH:13]=[CH:12]3)[CH:3]=1.[N-:18]=[N+:19]=[N-:20].[Na+].O>CN(C=O)C>[N:18]([C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][CH:13]=[CH:12]3)[CH:3]=1)=[N+:19]=[N-:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 574551565-((6-Chloropyrimidin-4-yl)oxy)-1H-indole

생성물 1

HCID 862347045-(6-Azido-pyrimidin-4-yloxy)-1H-indole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

490 mg (2.0 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-indole (WO 03/099771; Stage 163.1) and 260 mg (4.0 mMol) NaN3 in 3 ml DMF are stirred for 3 h at 90° C. Then the reaction mixture is poured into water and extracted three times with EtOAc. The organic layers are washed twice with water and brine, dried (Na2SO4) and concentrated, yielding the title compound: MS: [M+1]+=253.

후처리

  1. extractionextracted three times with EtOAc
  2. washThe organic layers are washed twice with water and brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-15e27e7259fb44428da90c0ce67e12f8
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855215B2

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