Water → 2-Amino-4,5-dichlorobenzoic acid

HRID 2265170

반응식

HRID 2265170 반응식
[NH2:1][C:2]1[CH:11]=[C:10]([Cl:12])[C:9]([Cl:13])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].O.[Li+].[OH-]>C1COCC1>[NH2:1][C:2]1[CH:11]=[C:10]([Cl:12])[C:9]([Cl:13])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 11694243Methyl 2-amino-4,5-dichlorobenzoate

생성물 1

HCID 121045502-Amino-4,5-dichlorobenzoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 2-amino-4,5-dichlorobenzoate (2.1 g, 9.41 mmol) was dissolved in THF (15 mL) and water (30 mL) was added. LiOH (0.79 g, 18.8 mmol) was added the mixture was stirred overnight at rt. The product was precipitated by addition of 10% aq. HCl (30 mL) and isolated by suction filtration. The white solid was dried under vacuum (1.6 g, 81%). 1H NMR (400 MHz, DMSO-d6): 7.78 (s, 1H), 7.01 (s, 1H).

후처리

  1. customThe product was precipitated by addition of 10% aq. HCl (30 mL)
  2. customisolated by suction filtration
  3. customThe white solid was dried under vacuum (1.6 g, 81%)

출처 및 근거

ORD 기록
ord-53b126169da841e7a3a20b968616c29c
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855292B2

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