2,1,3-Benzothiadiazole, 4-chlorosulfonyl- → 2-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4,5-dichloro-benzoic acid methyl ester

HRID 2265197

반응식

HRID 2265197 반응식
[NH2:1][C:2]1[CH:11]=[C:10]([Cl:12])[C:9]([Cl:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].Cl[S:15]([C:18]1[C:26]2[C:22](=[N:23][S:24][N:25]=2)[CH:21]=[CH:20][CH:19]=1)(=[O:17])=[O:16]>CN(C1C=CN=CC=1)C>[CH3:7][O:6][C:4](=[O:5])[C:3]1[CH:8]=[C:9]([Cl:13])[C:10]([Cl:12])=[CH:11][C:2]=1[NH:1][S:15]([C:18]1[C:26]2=[N:25][S:24][N:23]=[C:22]2[CH:21]=[CH:20][CH:19]=1)(=[O:17])=[O:16]

참가 물질

4

반응물 2

HCID 27354592,1,3-Benzothiadiazole, 4-chlorosulfonyl-HCID 11694243Methyl 2-amino-4,5-dichlorobenzoate

생성물 1

HCID 687705432-(Benzo[1,2,5]thiadiazole-4-sulfonylamino)-4,5-dichloro-benzoic acid methyl ester수율 50%

시약·촉매·용매 1

HCID 142844-(Dimethylamino)pyridine촉매

실험 절차

The title compound (0.95 g, 50%) was prepared from methyl 2-amino-4,5-dichlorobenzoate and 4-chlorosulfonyl-2,1,3-benzothiadiazole as in Example 1, Part A (without DMAP). 1H NMR (500 MHz, CDCl3): 11.21 (s, 1H), 8.39 (dd, J=7.1, 1.0, 1H), 8.25 (dd, J=8.8, 1.0, 1H), 7.94 (s, 1H), 7.91 (s, 1H), 7.74 (dd, J=8.8, 7.1, 1H), 3.93 (s, 3H).

출처 및 근거

ORD 기록
ord-d9fbe2007c7d42e192abe7170acdb79c
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855292B2

연결된 노트

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