Hydrochloric Acid → 2,3-dihydro-1H-indene-5-carboxylic acid

HRID 22653

반응식

HRID 22653 반응식
Cl[O-].[Na+].[CH2:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13](=[O:15])C)=[CH:10][CH:11]=2)[CH2:6][CH2:5]1.S(=O)(O)[O-:17].[Na+].Cl>O>[CH2:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([OH:15])=[O:17])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 2339761-(2,3-Dihydro-1H-inden-5-yl)ethan-1-oneHCID 23665760Sodium HypochloriteHCID 23665763Sodium Bisulfite

생성물 1

HCID 2328412,3-dihydro-1H-indene-5-carboxylic acid수율 95%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
55 °C

실험 절차

To a stirred 6% aqueous sodium hypochlorite solution in an oil bath to 55° C. is added 1-indane-5-yl-ethanone (1.0 g, 6.2 mmol). The solution is stirred at 55° C. for 2 h, followed by cooling to rt. Solid sodium bisulfite is added until the solution becomes clear. The mixture is diluted with water, followed by aqueous hydrochloric acid (6.0 M). The solid that forms is filtered and washed several times with water. The solid is dried under high vacuum at 60° C. for 5 h to afford 5-indancarboxylic acid as a white solid (0.96 g, 95%): 1H NMR (CDCl3) δ 8.0, 7.9, 7.3, 3.0, 2.1.

후처리

  1. temperatureby cooling to rt
  2. filtrationThe solid that forms is filtered
  3. washwashed several times with water
  4. customThe solid is dried under high vacuum at 60° C. for 5 h

출처 및 근거

ORD 기록
ord-d2af36b00ad946f0b17305882efe727c
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849620B2

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