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Phenyl Isothiocyanate → Phenylthiocarbamic acid O-(4-hydroxymethyl-5-oxo-2,3,4,5-tetrahydro-benzo[b]oxepin-4-ylmethyl) ester

HRID 2265824
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HRID 2265824 반응식
[OH:1][CH2:2][C:3]1([CH2:15][OH:16])[CH2:9][CH2:8][O:7][C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[C:4]1=[O:14].C(N(CC)CC)C.[C:24]1([N:30]=[C:31]=[S:32])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O1CCCC1>[OH:16][CH2:15][C:3]1([CH2:2][O:1][C:31](=[S:32])[NH:30][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:9][CH2:8][O:7][C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[C:4]1=[O:14]
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참가 물질

5

반응물 3

HCID 7673Phenyl IsothiocyanateHCID 8471TriethylamineHCID 670731254,4-Bis(hydroxymethyl)-3,4-dihydro-2H-benzo[b]oxepin-5-one

생성물 1

HCID 86633681Phenylthiocarbamic acid O-(4-hydroxymethyl-5-oxo-2,3,4,5-tetrahydro-benzo[b]oxepin-4-ylmethyl) ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4,4-bis(hydroxymethyl)-3,4-dihydro-2H-benzo[b]oxepin-5-one (500 mg, 2.25 mmol) in 28 ml of tetrahydrofuran were added, at room temperature, triethylamine (0.34 ml, 2.5 mmol) and phenyl isothiocyanate (672 μl, 5.63 mmol). The mixture was heated to reflux for 72 hours, concentrated and purified by column chromatography on silica gel (eluent: 1:1 tert-butyl methyl ether/cyclohexane). The product was obtained in a yield of 149 mg (19%).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 72 hours
  3. concentrationconcentrated
  4. custompurified by column chromatography on silica gel (eluent: 1:1 tert-butyl methyl ether/cyclohexane)
  5. customThe product was obtained in a yield of 149 mg (19%)

출처 및 근거

ORD 기록
ord-8aa5679a085849e1927ce31a861e643f
출처 데이터셋
uspto-grants-2010_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07858613B2

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