Sodium Hydroxide → (2-methyl-6-nitro-2H-indazol-3-yl)methanol
반응식
Br[CH2:2][C:3]1[N:4]([CH3:15])[N:5]=[C:6]2[C:11]=1[CH:10]=[CH:9][C:8]([N+:12]([O-:14])=[O:13])=[CH:7]2.[OH-:16].[Na+]>CC#N.O>[CH3:15][N:4]1[C:3]([CH2:2][OH:16])=[C:11]2[C:6]([CH:7]=[C:8]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:10]2)=[N:5]1참가 물질
5
실험 절차
3-(Bromomethyl)-2-methyl-6-nitro-2H-indazole (4.20 g, ˜14.9 mmol) in CH3CN (500 ml) and water (200 ml) was treated with NaOH to give pH˜11. The solution was stirred at rt for 2 days then conc. in vacuo and repeatedly extracted with dichloromethane and chloroform. The combined organic extracts were evaporated, and the crude product was purified by silica gel column chromatography to give (2-methyl-6-nitro-2H-indazol-3-yl)methanol (1.03 g, 33% TY). MS (ES+, m/z) 208.
후처리
- customto give pH˜11
- extractionconc. in vacuo and repeatedly extracted with dichloromethane and chloroform
- customThe combined organic extracts were evaporated
- customthe crude product was purified by silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-e9bc7907d3f64491a47e0ec6e422c76d
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07858626B2
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