Triphenylphosphine → HCID 68679430, 화합물

HRID 2265877노트

반응식

HRID 2265877 반응식
[F:1][C:2]1[CH:32]=[CH:31][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13]([N:16]3[CH2:25][CH2:24][C:23]4[C:18](=[CH:19][CH:20]=[C:21]([OH:26])[CH:22]=4)[CH:17]3[C:27]([O:29][CH3:30])=[O:28])(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O.[CH3:64][N:65]1[CH2:70][CH2:69][N:68]([CH2:71][CH2:72][CH2:73]O)[CH2:67][CH2:66]1>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([S:13]([N:16]3[CH2:25][CH2:24][C:23]4[C:18](=[CH:19][CH:20]=[C:21]([O:26][CH2:73][CH2:72][CH2:71][N:68]5[CH2:69][CH2:70][N:65]([CH3:64])[CH2:66][CH2:67]5)[CH:22]=4)[CH:17]3[C:27]([O:29][CH3:30])=[O:28])(=[O:14])=[O:15])=[CH:11][CH:12]=2)=[CH:31][CH:32]=1

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 792083-(4-Methyl-1-piperazine)propan-1-olHCID 5462977Diethyl azodicarboxylateHCID 68679822Methyl 2-[4-(4-fluorophenoxy)benzenesulfonyl]-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylate

생성물 1

HCID 68679430HCID 68679430, 화합물수율 76%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

250 mg (0.55 mmol) of methyl 2-[4-(4-fluorophenoxy)benzenesulfonyl]-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxlate are dissolved in 5 ml of THF. At room temperature, 216 mg (0.825 mmol) of triphenylphosphine, 142 μl (0.825 mmol) of DEAD and 120 mg (0.825 mmol) of 3-(4-methylpiperazin-1-yl)propan-1-ol are added, and the solution is stirred at room temperature for 18 hours. The solvent is then removed, and the residue is chromatographed on silica gel, allowing the desired product to be isolated as a colorless solid. Yield 76%.

후처리

  1. customThe solvent is then removed
  2. customthe residue is chromatographed on silica gel
  3. customto be isolated as a colorless solid

출처 및 근거

ORD 기록
ord-e929eec59fae4e6f8affd41005073166
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858619B2

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