Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methylpiperazine → N-(3-Ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-3-[2-(4-methyl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-yl]-acrylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide | HCID 74382385 | — |
| 생성물 | N-(3-Ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-3-[2-(4-methyl-piperazin-1-yl)-6-trifluoromethyl-pyridin-3-yl]-acrylamide | HCID 72335646 | 15% |
반응 단계
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (70 mg, 0.057 mmol) was reacted with N-methylpiperazine (30 μl) as in example 46 to give the title compound (13 mg, 15%) after recrystallization with Hex/EtOAc.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07858621B2 |
| 출처 데이터셋 | uspto-grants-2010_12 |
| ORD ID | ord-0fa91f094990421e9157804d00ca55ad |
| 출처 메모 | uspto-grants-2010_12 |