Propyl mercaptan → 3-(2-Propylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid

HRID 2266028노트

반응식

HRID 2266028 반응식
Cl[C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1.[CH2:17]([SH:20])[CH2:18][CH3:19].[H-].[Na+]>>[CH2:17]([S:20][C:2]1[C:7]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:6][CH:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[N:3]=1)[CH2:18][CH3:19]

참가 물질

4

반응물 3

HCID 7848Propyl mercaptanHCID 24758Sodium hydrideHCID 723356323-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid

생성물 1

HCID 687820003-(2-Propylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid수율 40.9%

실험 절차

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (243 mg, 0.966 mmol) was reacted with propanthiol (229 mg, 3.01 mmol) and sodium hydride (145 mg, 3.62 mmol) to afford title compound (115 mg) after purification by column chromatography (Hex EtOAc=2/3).

출처 및 근거

ORD 기록
ord-e2fdece70e554f36b9f05f95e76a3e8d
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858621B2

반응 노트

불러오는 중…