Sodium Hydroxide → 1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

HRID 2266407노트

반응식

HRID 2266407 반응식
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Br:17])[CH:12]=2)[CH:10]=1)=[O:5])C.[OH-].[Na+]>CO>[Br:17][C:13]1[CH:12]=[C:11]([N:9]2[CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=[CH:8]2)[CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 161287541-(3-Bromo-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester

생성물 1

HCID 234449541-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

To a solution of 3 (0.5 g, 1.7 mmol) in methanol (25 mL) was added aqueous NaOH (2M; 4.3 mL) and the reaction mixture was stirred at 40° C. for 0.5 h. Methanol was removed in vacuo and the water layer acidified and extracted with ethyl acetate, dried, filtered and evaporated to dryness. The crude compound was used as such for the next step.

후처리

  1. customMethanol was removed in vacuo
  2. extractionextracted with ethyl acetate
  3. customdried
  4. filtrationfiltered
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-a05c09233d764bc3a16937b3089a19dd
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858649B2

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