Methanol → [7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic Acid

HRID 2266450노트

반응식

HRID 2266450 반응식
C[O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]2[C:6]=1[C:7]([CH3:25])=[C:8]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[C:9]([CH3:16])=[N:10]2.CO.O.[OH-].[Li+]>C(O)(=O)C>[Cl:15][C:13]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:25])=[C:8]([CH2:17][C:18]3[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=3)[C:9]([CH3:16])=[N:10]2)=[C:5]([CH2:4][C:3]([OH:26])=[O:2])[CH:14]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 68782352[7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic Acid Methyl Ester

생성물 1

HCID 57742513[7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic Acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of [7-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-yl]acetic acid methyl ester (0.24 g), methanol (10 mL), water (2.0 mL) and saturated aqueous lithium hydroxide solution (1.0 mL) was stirred at room temperature for 17 hours. The pH of the solution was adjusted to 5 by the addition of glacial acetic acid and the methanol removed under reduced pressure. The resulting precipitate was collected by filtration and washed with water. Crystallisation of the solid from ethyl, acetate gave title compound as a fluffy white solid, 0.16 g

후처리

  1. customthe methanol removed under reduced pressure
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customCrystallisation of the solid from ethyl, acetate

출처 및 근거

ORD 기록
ord-fb659d0830a646f580525d3347b4a0ac
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858640B2

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