Methanol → HCID 57742524, 화합물

HRID 2266544노트

반응식

HRID 2266544 반응식
C[O:2][C:3](=[O:33])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]2[C:7]=1[C:8]([CH3:32])=[C:9]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:24][CH:23]=1)[C:10]([O:17][CH:18]([F:20])[F:19])=[N:11]2.CO.[OH-].[Li+].O>C(O)(=O)C>[F:20][CH:18]([F:19])[O:17][C:10]1[C:9]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([S:28]([CH3:31])(=[O:29])=[O:30])=[CH:24][CH:23]=2)=[C:8]([CH3:32])[C:7]2[C:12](=[C:13]([F:16])[CH:14]=[CH:15][C:6]=2[O:5][CH2:4][C:3]([OH:33])=[O:2])[N:11]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 68782706HCID 68782706, 화합물

생성물 1

HCID 57742524HCID 57742524, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of [2-difluoromethoxy-8-fluoro-3-(4-methanesulfonylbenzyl)-4-methylquinolin-5-yloxy]acetic acid methyl ester (0.57 g), methanol (24 mL), 5.0 M aqueous lithium hydroxide solution (0.5 mL) and water (1.0 mL) was stirred at room temperature for 90 minutes. The pH of the mixture was adjusted to 4 by the addition of glacial acetic acid and the solvent removed under reduced pressure. The residue was diluted with water and the solid collected by filtration, washed with water and dried to afford to title compound as a white solid, 0.53 g.

후처리

  1. customthe solvent removed under reduced pressure
  2. additionThe residue was diluted with water
  3. filtrationthe solid collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-0514dd4db473422182e957d42feb5b54
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858640B2

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