Acetic Acid → N-(2-fluoro-5-nitrophenyl)acetamide

HRID 2266558노트

반응식

HRID 2266558 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[NH2:18].C(O)(=O)C>O>[F:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[NH:18][C:5](=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 677852-Fluoro-5-nitroaniline

생성물 1

HCID 2779405N-(2-fluoro-5-nitrophenyl)acetamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

Acetic anhydride (8.0 mL) was added dropwise over a period of 10 minutes to a mixture of 2-fluoro-5-nitrophenylamine (7.8 g) and acetic acid (50 mL) at reflux. The resulting mixture was heated at reflux for 30 minutes and cooled to 40° C. The mixture was poured into cold water (800 mL) and the resulting precipitate collected by filtration, washed with 1.0 M aqueous hydrochloric acid and water and dried to give title compound as a light brown solid, 9.2 g.

후처리

  1. temperatureat reflux
  2. temperatureThe resulting mixture was heated
  3. temperatureat reflux for 30 minutes
  4. filtrationthe resulting precipitate collected by filtration
  5. washwashed with 1.0 M aqueous hydrochloric acid and water
  6. customdried

출처 및 근거

ORD 기록
ord-08fed089b01c4df39708421871d8ce18
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858640B2

반응 노트

불러오는 중…