Water → 2-Chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-ol

HRID 2266632노트

반응식

HRID 2266632 반응식
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][C:7]2[C:8](=O)[NH:9][C:10]3[C:15]([C:16]=2[CH3:17])=[C:14]([OH:18])[CH:13]=[C:12]([CH3:19])[CH:11]=3)=[CH:4][CH:3]=1.O.P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:8]1[C:7]([CH2:6][C:5]2[CH:21]=[CH:22][C:2]([Cl:1])=[CH:3][CH:4]=2)=[C:16]([CH3:17])[C:15]2[C:14]([OH:18])=[CH:13][C:12]([CH3:19])=[CH:11][C:10]=2[N:9]=1

참가 물질

4

반응물 3

HCID 962WaterHCID 24813Phosphorus oxychlorideHCID 686078103-(4-chlorobenzyl)-5-hydroxy-4,7-dimethyl-1H-quinolin-2-one

생성물 1

HCID 1363359252-Chloro-3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-ol

실험 절차

A solution of 3-(4-chlorobenzyl)-5-hydroxy-4,7-dimethyl-1H-quinolin-2-one (1.8 g) in phosphorus oxychloride (9.0 mL) was heated at 180° C. in a microwave reactor for 15 minutes. The solution was poured onto a mixture of ice and water and the resulting precipitate collected by filtration, washed with water and then dried to afford title compound, 2.3 g.

후처리

  1. filtrationthe resulting precipitate collected by filtration
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-722860ea07a14d929f56a7c3a0d264e3
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858640B2

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