2-Chloro-4-cyanopyridine → 2-{[3-(Hydroxymethyl)phenyl]sulfanyl}pyridine-4-carbonitrile

HRID 2267055

반응식

HRID 2267055 반응식
[SH:1][C:2]1[CH:3]=[C:4]([CH2:8][OH:9])[CH:5]=[CH:6][CH:7]=1.Cl[C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][N:18]=1)[C:14]#[N:15]>>[OH:9][CH2:8][C:4]1[CH:3]=[C:2]([S:1][C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][N:18]=2)[C:14]#[N:15])[CH:7]=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 5686382-Chloro-4-cyanopyridineHCID 12813879(3-Sulfanylphenyl)methanol

생성물 1

HCID 573554602-{[3-(Hydroxymethyl)phenyl]sulfanyl}pyridine-4-carbonitrile수율 63%

실험 절차

Using the method of Preparation 155 using (3-mercaptophenyl)methanol (6.00 g, 42.8 mmol) and 2-chloroisonicotinonitrile (5.65 g, 40.8 mmol) affords the title compound (6.22 g, 63%): 243 (M+H, 100%).

출처 및 근거

ORD 기록
ord-fbdd8d9bcd8b49b0b4efc5c1269dd9f1
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858646B2

연결된 노트

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