Chloroform → 4-[1-Phenyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetra-hydropyridine-1-carboxylic acid tert-butylamide

반응식

[C:1]1([N:7]2[CH:11]=[C:10]([C:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH:17]=3)[N:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(Cl)Cl.[C:22]([N:26]=[C:27]=[O:28])([CH3:25])([CH3:24])[CH3:23]>N1C=CC=CC=1>[C:22]([NH:26][C:27]([N:15]1[CH2:14][CH:13]=[C:12]([C:10]2[N:9]=[N:8][N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:11]=2)[CH2:17][CH2:16]1)=[O:28])([CH3:25])([CH3:24])[CH3:23]

참가 물질

실험 절차

4-[1-Phenyl-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetra-hydropyridine (35 mg) prepared in Example 49 was dissolved in 1 ml of pyridine and 1 ml of chloroform and 26 μl of tert-butyl isocyanate was added thereto followed by stirring at room temperature for 6 hours. The reaction solution was concentrated in vacuo and the resulting residue was separated and purified by a preparative thin-layer chromatography (chloroform/methanol=10/1+0.3% aqueous ammonia) and then recrystallized from chloroform-hexane to give 42 mg of the title compound as a white solid.