Chloroacetaldehyde → N-(4-Fluorophenyl)thiazol-2-amine

HRID 2267397

반응식

HRID 2267397 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[CH:4][CH:3]=1.Cl[CH2:13][CH:14]=O.C(OCC)(=O)C>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]2[S:10][CH:13]=[CH:14][N:11]=2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 33ChloroacetaldehydeHCID 8857Ethyl AcetateHCID 6930614-Fluorophenylthiourea

생성물 1

HCID 25093329N-(4-Fluorophenyl)thiazol-2-amine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

1-(4-fluorophenyl)thiourea (2.00 g, 11.7 mmol) and 2-chloroacetaldehyde (3.72 mL, 58.6 mmol) in anhydrous ethanol (5 mL) were added to a microwave vial. The reaction mixture was heated to 80° C. in a microwave reactor for 20 min. On cooling, ethyl acetate (2 mL) was added to the crude product reaction mixture and pure product crystallized out. This filtered off, washed with hexane and air-dried to afford the title compound as a crystalline brown solid, 1.568 g. MS (M+H)+ 195.

후처리

  1. temperatureOn cooling
  2. customcrystallized out
  3. filtrationThis filtered off
  4. washwashed with hexane
  5. customair-dried

출처 및 근거

ORD 기록
ord-3dbbb6f50cdb465bb2efdb4163b817a9
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858785B2

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