Dimethylformamide dimethyl acetal → 2-(2-Bromothiophene-5-carbonyl)-3-(dimethylamino)acrylonitrile

반응식

[Br:1][C:2]1[S:6][C:5]([C:7](=[O:11])[CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Br:1][C:2]1[S:6][C:5]([C:7]([C:8](=[CH:14][N:15]([CH3:17])[CH3:16])[C:9]#[N:10])=[O:11])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 78373Dimethylformamide dimethyl acetal

HCID 112876633-(5-Bromothiophen-2-yl)-3-oxopropanenitrile

생성물 1

HCID 543239012-(2-Bromothiophene-5-carbonyl)-3-(dimethylamino)acrylonitrile

반응 조건

온도: 100 °C

실험 절차

3-(5-Bromothiophen-2-yl)-3-oxopropanenitrile (4 g, 17 mmol) was treated with dimethyl formamide dimethylacetal and the mixture heated to 100° C. After 1 h, the mixture was allowed to cool down to room temperature. The yellow solid that precipitated was collected by suction filtration and washed well with diethyl ether. Yield=4.6 g. MS (M+H)+ 284.

후처리

temperatureto cool down to room temperature
filtrationThe yellow solid that precipitated was collected by suction filtration
washwashed well with diethyl ether

출처 및 근거

ORD 기록: ord-ec1d5003758443f987bfc3889ea3699f
출처 데이터셋: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07858785B2

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