Hydrochloric Acid → Piperidin-4-yl pivalate

HRID 2267705노트

반응식

HRID 2267705 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl>CO.[Pd]>[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15](=[O:20])[C:16]([CH3:18])([CH3:17])[CH3:19])[CH2:10][CH2:9]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 668415652,2-Dimethyl-propionic acid 1-benzyl-piperidin-4-yl ester

생성물 1

HCID 57464983Piperidin-4-yl pivalate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of piperidine 51 (35.99 g, 130.7 mmol) in methanol is hydrogenated with Pd/C in the presence of one equivalent of HCl (104.5 ml, 130.7 mmol, 1.25M in MeOH). After filtration and evaporation, the crude is taken up in ether and washed with 1N—NaOH and brine. Drying, evaporation and distillation (0.08 mbar, 75-90 C) gave a colourless oil. Yield: 17.98 g (74%).

후처리

  1. filtrationAfter filtration and evaporation
  2. washwashed with 1N—NaOH and brine
  3. customDrying
  4. customevaporation and distillation (0.08 mbar, 75-90 C)
  5. customgave a colourless oil

출처 및 근거

ORD 기록
ord-6331622090a44f008539bbb5c8ccca71
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858781B2

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