Water → Allyl 4-formylbenzoate

HRID 2268212노트

반응식

HRID 2268212 반응식
[H-].[Na+].[CH:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)=[O:4].[CH2:14](Br)[CH:15]=[CH2:16].O>CN(C=O)C>[CH:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([O:11][CH2:16][CH:15]=[CH2:14])=[O:10])=[CH:7][CH:6]=1)=[O:4]

참가 물질

6

반응물 4

HCID 962WaterHCID 7841Allyl bromideHCID 120884-Formylbenzoic acidHCID 24758Sodium hydride

생성물 1

HCID 18381245Allyl 4-formylbenzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

3.8 g (12 mmol) of sodium hydride (80% in oil) and 100 ml of DMF are introduced into a three-necked flask under a stream of nitrogen. A solution of 15 g (10 mmol) of 4-formylbenzoic acid in 100 ml of DMF is added dropwise and the mixture is stirred until the evolution of gas has ceased. 10 ml (12 mmol) of allyl bromide are then added and the mixture is stirred at room temperature for four hours. The reaction medium is poured into water and extracted with ethyl ether, and the organic phase is separated out after settling has taken place, dried over magnesium sulphate and evaporated. 17.2 g (90%) of the expected allyl ester are collected in the form of a yellow oil.

후처리

  1. stirringthe mixture is stirred at room temperature for four hours
  2. extractionextracted with ethyl ether
  3. customthe organic phase is separated out after settling
  4. dry with materialdried over magnesium sulphate
  5. customevaporated
  6. custom17.2 g (90%) of the expected allyl ester are collected in the form of a yellow oil

출처 및 근거

ORD 기록
ord-1674d0cdf5134149b582b907c3e60340
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06326510B1

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