Ammonia → HCID 178447010, 화합물

HRID 2269022노트

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HRID 2269022 반응식
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:24]C)[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.N>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:24])[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 110242996-Amino-9-benzyl-8-methoxy-2-pentoxypurine

생성물 1

HCID 178447010HCID 178447010, 화합물수율 86.2%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

6-Amino-9-benzyl-8-methoxy-2-pentoxypurine (40 mg, 0.117 mmol) in concentrated hydrochloric acid (20 ml) was stirred for 12 hours at room temperature. The reaction mixture was made basic with 28% aqueous ammonia. The resulting crystals were filtered and washed with water to give the subject compound (33 mg, yield 86%).

후처리

  1. filtrationThe resulting crystals were filtered
  2. washwashed with water

출처 및 근거

ORD 기록
ord-3dd530392f6c4f4c94c6f62c18bf6585
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329381B1

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